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Scientist/Sr. scientist of analytical development – oligonucleotide

OliX Pharmaceuticals, Inc.

This is a Full-time position in San Diego, CA posted December 16, 2019.

Job SummaryOliX US is seeking a Scientist/Sr.

Scientist of Analytical Development to join the Oligonucleotide Chemistry Team in San Diego, California.

The successful candidate will be responsible for the analysis and characterization of chemically modified oligonucleotides, development of new analytical methods of siRNA for pre-clinical through clinical development. ResponsibilitiesData analysis of chemically synthesized siRNA: LC-MS, UV-Vis, IEX, RP, and IPRP for purity determination and sequence characterizationAnalytical characterization of single-strand RNA for purity determination and impurity profilingSupporting of the duplex annealing processPurity determination and characterization of annealed siRNADevelopment and qualification of new methods for siRNAPerforming routine analyses as neededAnalysis and re-qualification of early phase siRNAOperating, maintaining, and troubleshooting analytical instruments as neededEndotoxin analysis of siRNA is a plusConducting laboratory work in a safe, efficient manner that ensures a safe working environmentAbility to complete assignments and meet deadlines and time schedulesPreparation of written methods and SOPsKeeping an accurate record of the experiments and summarize the results in written reportsPossess excellent written and verbal communication skillsDemonstrate an ability to work as part of a team and possess an excellent work ethicQualificationsPh.D.

in Analytical Chemistry 2-4 years experience in biopharmaceutical experience with demonstrated chromatographic separation and characterizationExperience in Empower, Chemistation, XCalibur or ProMass are preferredOptimization of HPLC and LC-MS methodStrong knowledge of chromatographic separation mechanismsKnowledge and hands-on experience with various analytical techniques such as HPLC, LC-MS, LAL (kinetic), GC, CGE (capillary gel electrophoresis), UV-Vis and NMRBasic understanding of GMP/GLP with ICH and FDA Guidance is a plusOliX US Inc.

is a subsidiary company of OliX Pharmaceuticals that is a biopharmaceutical company in South Korea focusing on next-generation nucleic acid-based therapeutics based on RNA interference (RNAi) technology.

OliX has its own proprietary RNAi structure and secures “freedom-to-operate”.

OliX US offers competitive wages and a full benefits package, including medical, dental, vision, LTD, and 401K.

 Seniority LevelMid-Senior level IndustryBiotechnologyPharmaceuticalsEmployment TypeFull-timeJob FunctionsResearchScienceAnalyst